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2005
Role of ATM in the Control and Execution of
Apoptosis: Crosstalk Between ATM and Abl Kinases and Caspases
Daniela Barilá, PhD - Dulbecco
Telethon Institute at University of Tor Vergata
Down Regulation of Nucleophosmin (NPM): A
New Mechanism to Activate p53 in AT Cells
France Carrier, PhD - University of
Maryland, Baltimore
Perinatal
Implantation of Human Glial Progenitor Cells as a Treatment Strategy
for the Childhood Myelin Disorders
Steven A. Goldman, PhD - Cornell University
The Zebrafish as a Novel Model System of Ataxia-Telangiectasia and
Other Related Diseases
Shuji Kishi,
M.D., PhD - Instructor in Pathology, Harvard Medical School
Correction of
the neurological defect in Atm gene-disrupted mice by the
insoindolin nitroxide, 5
carbocy-1,1,3,3-tetramethylisoindoline-2-yloxyl (CTMIO)
Martin F.
Lavin, PhD - Queenslands Institute of Medical Research
Lung Function
in Ataxia-Telangiectasia
Sharon McGrath, MD - Johns Hopkins School of Medicine
Functional
Interactions between ATM,E2F1 and the M/R/N DNA repair complex.
Tanya T. Paull, PhD - The University of Texas at
Austin
Exploration of the Function of ATM in Glial
Biology
Prithi Rajan, PhD - The Burnham Institute
Iron Chelators as a Pharmacological
Treatment to Reduce Spontaneous dsDNA Breaks in
Ataxia-Telangiectasia Cells
Rodney Shackelford - Louisiana State University at Shreveport
Aberrant Regulation of Mitochondrial DNA in Ataxia-telangiectasia
Gerald S. Shadel,
PhD -
Yale University
School of Medicine
Understanding ATM
Yossi Shiloh, PhD - Tel Aviv
University
Top
2004
A-T Clinical Center
Johns Hopkins University
Gene Therapy for Ataxia-Telangiectasia
Maria Luisa Cortes, PhD - Massachusetts General Hospital
Generation of a Rat Model for
Ataxia-Telangiectasia
Martin F.
Lavin, PhD - Queenslands Institute of Medical Research
and Michael M. Weil, PhD - Colorado State University
ATM Activates
the Myocyte Enhancer Factor-2 (MEF2) Family of Transcription Factors
Implicated in Regulation of Neuronal Differentiation and Survival
Stuart
Lipton, MD, PhD - The Burnham Institute
The Function
of ATM in Neuronal Differentiation: Identification of Targets for High
Throughput Screening
Brendan
Price, PhD - Dana-Farber Cancer Institute
ATM Gene
Transfer for Ataxia-Telangiectasia by a Novel Herpes Amplicon Vector
Suming Wang,
MD, PhD
Understanding ATM
Yossi Shiloh, PhD - Tel Aviv
University
Top
2003
A-T Clinical Center
Johns Hopkins University
The Role of Atm Protein in
the DNA Damage Response in Cerebellar Neuronal Cells
Ari Barzilai, PhD - Tel Aviv
University
New Mechanisms to Activate p53 Function in A-T Cells
France Carrier, PhD - University
of Maryland
Induction for Hematopoietic
Chimerism for Treatment of Immune System Defects in
Ataxia-Telangiectasia
John Iacomini, PhD -
Massachusetts General Hospital
ATM Modulation of CREB Phosphorylation in the
Developing Thymus, Testes and Cerebellum
Wenan Qiang, PhD - Northwestern University
Feinberg School of Medicine
Understanding ATM
Yossi Shiloh, PhD - Tel Aviv
University
Developing PARP Inhibitors
that can Penetrate the Blood Brain Barrier by Oral Dosing
Jir Zhang, PhD - Guilford Pharmaceuticals, Inc.
Desferrioxamine as a Pharmacological
Treatment to Increase the Life-Span of Ataxia-Telangiectasia Mice
Suming Wang, MD, PhD
Cell Cycle Events in Ataxia-Telangiectasia:
Human and Mouse
Yan Yang, MD, PhD
The Role of ATM in the Mitochondrial Pathway of Apoptosis
Leman Yel, MD - University
of California, Irvine
Top
2002
A-T Clinical Center
Johns Hopkins University
Pilot Study: Evaluating the Relative Radiation Sensitivity of ATM
Functional & ATM Inactive Human Cell Lines After Treatment With
Small-Molecule Modulators
SRI International
Glucocorticoid Mimics Functional ATM Kinase to Prevent Thymic
Lymphoma Development in Atm -/- Mice
Mingshan Yan, MD -
University of Texas MD Anderson Cancer Center
A Drosophila Model for Ataxia-Telangiectasia
Shelagh Diane Campbell, PhD
- University of Alberta
Understanding ATM
Yossi Shiloh, PhD - Tel Aviv
University
Induction for Hematopoietic Chimerism for Treatment of Immune
System Defects in Ataxia-Telangiectasia
John Iacomini, PhD -
Massachusetts General Hospital
Creation of a Transgenic Porcine Model of A-T
Christopher Counter, PhD -
Duke University
A Novel Alternative Model System for Identifying Candidate
Therapeutics for Ataxia-Telangiectasia
Shuji Kishi, MD, PhD -
Dana-Farber Cancer Institute
Experimental Gene Therapy for Ataxia-Telangiectasia
Xandra O. Breakefield, PhD -
Massachusetts General Hospital
Effect of EUK - 189 on Motor Performance (Rotarod), Oxidative
Damage Markers, and Survival in ATM Knockout Mice
M. Flint Beal, MD - Cornell
University Medical College
Linking ATM and Breast Cancer
Kevin D. Brown, PhD -
Louisiana State University Health Sciences Center
Telomeres, Telomerase and Lifespan of Brain Cells of ATM Null Mice
Tej K. Pandita, PhD -
Washington School of Medicine
Top
2001
A-T Clinical Center
Johns Hopkins University
Overlapping Functions of ATM and ATX in Genome and RNA Surveillance
Robert T. Abraham, PhD -
Burnham Institute
Molecular Basis of Pleiotropic Phenotypes of Ataxia-Telangiectasia
Jun Qin, PhD - Baylor
College of Medicine
Understanding ATM - Multi-year Grant
Yossi Shiloh, PhD - Tel Aviv
University
Strain Background Effects on Atm Nullizygosity
Michael M. Weil, PhD -
University of Texas MD Anderson Cancer Center
Identification of Novel ATM-RAD 17 Associated Proteins that
Function as Regulators or Downstream Targets
Xiao-Fan Wang, PhD - Duke
University Medical Center
Telomeres, Telomerase and Lifespan of Brain Cells of ATM Null Mice
Tej K. Pandita, PhD -
Columbia University
Effect of loss of ATM on Glial Cell Function
Martin F. Lavin, PhD -
Queenslands Institute of Medical Research
Top
2000
A-T Clinical Center
Johns Hopkins University
Experimental Gene Therapy for A-T Using HSV Amplicon Vectors
Xandra Breakefield, PhD -
Massachusetts General Hospital
ATM Gene Transfer for Ataxia-Telangiectasia by a Novel Herpes
Amplicon Vector
Suming Wang, MD, PhD - Human
Gene Therapy Research
Institute
Development of DNA Diagnostic Test for the Ataxia-Telangiectasia
(ATM) Gene
A-T Clinical Center at Johns
Hopkins University
Neurologic Pathophysiology of Ataxia-Telangiectasia
A-T Clinical Center at Johns
Hopkins University
Understanding ATM - Multi-year Grant
Yossi Shiloh, PhD - Tel Aviv
University
Molecular Role of Oxidative Stress in
Cerebellar Degeneration in A-T
Ari Barzilai, PhD - Tel Aviv
University
Mouse Ataxia-Telangiectasia Intervention Study
M. Flint Beal, MD - Cornell University Medical College
Ataxia-Telangiectasia: An Assessment of Global Biochemical
Abnormalities
David S. Lawrence, PhD -
Albert Einstein College of Medicine
Production of ATM Gene-Targeted Pigs and Cattle by Nuclear Transfer
from Cultured Fibroblast Cells
Steven Stice, PhD -
University of Georgia
Top
1999
A-T Clinical Center
Johns Hopkins University
Neural Autoantibodies in the Sera of A-T Patients
Robert B. Darnell, MD, PhD -
Rockefeller University
Mechanisms of Cytokine-Mediated Neuroprotection in ATM Mutant Mice
Lorise C. Gahring, PhD -
University of Utah School of Medicine
Regulation of the Aspergillus DNA Damage Response by Suppressors of
ATM Kinase Mutations
Steven D. Harris, PhD -
University of Connecticut Health Center
ATR-Activating Therapy for Ataxia-Telangiectasia
Robert T. Abraham, PhD -
Duke University Medical Center
Ataxia-Telangiectasia: Activation of Cytoprotective Signaling
Pathways
David S. Lawrence, PhD - The
Albert Einstein College of Medicine
Neural Stem Cell Transplantation in Animal Models of A-T
Evan Y. Snyder, MD, PhD -
Children’s Hospital Boston
Generation of Immunological Reagents to Atm, the Mouse Homolog of
the ATM Gene Product
Kevin D. Brown, PhD -
Louisiana State University Medical Center
Molecular Basis of Pleiotropic Phenotypes of Ataxia-Telangiectasia
Jun Qin, PhD - Baylor
College of Medicine
Development of Improved Protective Strategies Against Free Radical
Damage in Ataxia-Telangiectasia
Michael H.L. Green, PhD -
University of Brighton
Cloning the Murine Atm Gene
Suming Wang, MD, PhD - Human
Gene Therapy Research Institute
A Primate Model for Ataxia-Telangiectasia
Don Wolf, PhD - Oregon
Health Sciences University
DNA Damage Signaling in
ATM-/- Neurons
Herbert M. Geller, PhD -
University of Medicine and Dentistry of New Jersey - Robert Wood
Johnson Medical School
Top
1998
A-T Clinical Center
Johns Hopkins University
Ocular Manifestations of Ataxia-Telangiectasia - A Prospective
Study
Arman K. Farr, MD - The
Wilmer Ophthalmological Institute
Characterization of ATM Kinase Activity
Yossi Shiloh, PhD - Tel Aviv
University
Use of Atm Deficient and Atm/Rag2 Deficient Mice to Assess
Abnormalities in Eye Movements and Associated Brain Pathology
Carrolee Barlow, MD, PhD -
The Salk Institute for Biological Studies
Defects in Cerebellar Purkinje Cell Properties May Underlie Ataxias
in Ataxia-Telangiectasia
Peter H. Reinhart, PhD -
Duke University Medical Center
Brain Pathology in ATM-deficient Mouse: Correlating Structure and
Functions
Menahem Segal, PhD - The
Weizmann Institute
Gene Therapy for Ataxia-Telangiectasia by a Novel Herpes Amplicon
Vector
Suming Wang, MD, PhD - Human
Gene Therapy Research Institute
Defining a Minimal Functional Domain Within the ATM Gene Product
Kevin D. Brown, PhD -
Louisiana State University Medical Center
Molecular Mechanism of Cerebellar Degeneration in A-T
Ari Barzilai, PhD - Tel Aviv
University
Role of the Extranuclear ATM Protein in Neuronal Function
Martin F. Lavin, PhD -
Queensland Institute of Medical Research
Biochemical Analysis of the Ataxia-
Telangiectasia Gene Product ATM and Its Relative ATR
Stephen P. Jackson, PhD -
University of Cambridge
Top
1997
A-T Clinical Center
Johns Hopkins University
Experiments on Ectopic Expression of the ATM Protein and the
Production of Polyclonal and Monoclonal Antibodies Against the ATM
Protein
Yossi Shiloh, PhD - Tel Aviv
University
ATM in Neurodegeneration
Eva Y.-H.P. Lee, MD, PhD -
University of Texas Health Science Center
Role of Purkinje Cell Specific Interacting Partners in ATM Function
Ines Ibanez-Tallon, PhD -
The Rockefeller University
Nitric Oxide-Synthesizing Neurons in Pathology of A-T
Rodrigo O. Kuljis, MD -
University of Miami School of Medicine
Oxidative Stress and Antioxidants in Ataxia-Telangiectasia
Gerald Cohen, PhD - Mount
Sinai School of Medicine
ATM-related Checkpoint Pathway in Saccharomyces cerevisiae
David F. Stern, PhD - Yale
University School of Medicine
Contribution of Reactive Oxygen Species to Neuronal Vulnerability
in Ataxia-Telangiectasia
Laura L. Dugan, MD -
Washington University School of Medicine
Functions of ATM Protein in Neurodevelopment
Rosalind A. Segal, MD, PhD -
Beth Israel Deaconess Medical Center
Responses to DNA Damage in Cerebellar Neurons of Atm Mice
Piergiorgio Strata, MD, PhD
- University di Torino
Poly (ADP-ribose) Polymerase and Oxidative Stress in
Ataxia-Telangiectasia
Joe M. McCord, PhD -
University of Colorado Health Sciences Center
Mechanisms of Neuronal Pathogenesis in Ataxia-Telangiectasia
Yang Xu, PhD - University of
California, San Diego
Top
1996
A-T Clinical Center
Johns Hopkins University
Translational Regulation of ATM Expression
Orna Elroy-Stein, PhD - Tel
Aviv University
Purkinje Cell Development in Genetic Murine Model of
Ataxia-Telangiectasia: Effects of Atm Gene Knock-out Purkinje Cell
Morphogenesis, Survival and Responsiveness to Neurotrophic Factors
Howard T.J. Mount, PhD - Robert
Wood Johnson Medical School
The Mechanism of Neurodegeneration in Ataxia-Telangiectasia
Peter J. McKinnon, PhD - St.
Jude Children’s Research Hospital
Purification and Biochemical
Analysis of the Ataxia-Telangiectasia Gene Product and Identification
of Accessory Proteins
Stephen P. Jackson, PhD -
University of Cambridge
A Mouse Model for Ataxia-Telangiectasia
David Baltimore, PhD -
Massachusetts Institute of Technology
Top
1995
A-T Clinical Center
Johns Hopkins University
Characterization of the Saccharomyces cerevisiae Homologues, HAT1
and MEC1, of the Human Gene ATM Mutated in Ataxia-Telangiectasia
Dwight M. Morrow, PhD - John
Hopkins University
Ataxia-Telangiectasia: From Gene Back to Phenotype
Yossi Shiloh, PhD - Tel Aviv
University
MEC1: Understanding its Multiple Functions in Yeast and Relevance
to ATM
Ted Weinert, PhD -
University of Arizona
The Drosophila mei-41 Gene: An Animal Model for
Ataxia-Telangiectasia
Scott Hawley, PhD -
University of California at Davis
Top
1994
Complementation of A-T Radioresistant DNA Synthesis by Human Gene
Transfer
Timothy J. Jorgensen, PhD -
Georgetown
University Medical Center
Cloning of genes involved in the induction of neuronal death
Santosh D’Mello, PhD -
University of Connecticut
Mechanisms of Neuronal PCD
Eugene M. Johnson, PhD -
Washington University Medical School
Lymphocyte Biology and Epstein-Barr Virus Activation in
Ataxia-Telangiectasia
Donald E. Mosier, MD, PhD -
Scripps Research Institute
Protein Kinase C and the A-T Dependent Response to Ionizing
Radiation
Michael Christman, PhD -
University of California, San Francisco
Complementation of A-T Groups and A-T Gene Function
Michael B. Kastan, MD, PhD -
Johns Hopkins Oncology Center
Localization of the A-T Gene
Aslihan Tolun, PhD -
Bogazici University (Collaboration with Patrick Concannon)
Top
1993
Ataxia-Telangiectasia, From Phenotype to Genes
Yossi Shiloh, PhD - Tel Aviv
University
Anomalies in cell cycle control in ataxia-Telangiectasia
post-irradiation
Martin F. Lavin, PhD -
Queensland Institute of Medical Research
Characterization of a Candidate Gene for Ataxia-Telangiectasia
Leon Kapp, PhD - SRI
International
Isolation and Functional Characterization of the Gene for
Ataxia-Telangiectasia
Glen A. Evans, MD, PhD - Salk
Insitute for Biological Studies
Cloning the Ataxia-Telangiectasia Gene
Michael Swift, MD - New York
Medical College
Isolation of a Gene for Ataxia-Telangiectasia
Richard A. Gatti, MD - UCLA School of Medicine
Isolation of Ataxia-Telangiectasia Genes by cDNA Complementation
Stephen Meyn, MD, PhD - Yale
University School of Medicine
Molecular Analysis of Cellular Responses to Ionizing Radiation in
Ataxia-Telangiectasia
Kathleen Dixon, PhD -
University of Cincinnati
Top
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